Effects of Erchen Decoction and Changpu Yujin Decoction on cognitive function in obsctive sleep apnea-hypopnea syndrome patients
Objective:To investigate the effects of Erchen Decoction and Changpu Yujin Decoction on cognitive function in patients with obsctive sleep apnea-hypopnea syndrome(OSAHS).Methods:Ninety patients with OSAHS complicated with cognitive function impairment were randomly divided into non-invasive ventilator group,traditional Chinese medicine treatment group and traditional Chinese medicine+non-invasive ventilator group,with 30 cases in each group.The changes of apnea hypopnea index(AHI),minimum blood oxygen saturation(LSaO2),Montreal Scale(MoCA)score,serum hydroxyl radical inhibition(·OH)and total antioxidant capacity(TAOC)were observed before and after treatment.Results:After treatment,LSaO2,MoCA score,inhibition·OH ability and TAOC were increased(P＜0.05),and AHI was decreased(P＜0.05)in all groups compared with before treatment.Compared with non-invasive ventilator group and traditional Chinese medicine group after treatment,LSaO2,MoCA scores,inhibition·OH ability and TAOC in traditional Chinese medicine+non-invasive ventilator group were higher(P＜0.05),and AHI was lower(P＜0.05).Compared with non-invasive respiratory group after treatment,LSaO2,MoCA score,inhibition·OH ability and TAOC in Chinese medicine treatment group were lower(P＜0.05),and AHI was higher(P＜0.05).Conclution:Erchen Decoction and Changpu Yujin Decoction combined with non-invasive ventilator can improve cognitive function in patients with obstructive sleep apnea hypoventilation syndrome,and the mechanism may be realized by inhibiting oxidative stress.
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