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HIV/AIDS中医证候研究现况与展望

Current status and prospect of the traditional Chinese medicine syndrome of HIV/AIDS

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HIV/AIDS是复杂疑难性疾病,目前尚无有效的治愈方法.HIV/AIDS证候是辨证施治的核心,开展证候演变规律及物质基础研究是探索证候实质、筛选药物作用靶点、研发有效方剂、提高临床疗效关键环节.笔者通过梳理HIV/AIDS证候研究现况及临床实践,总结出了HIV/AIDS证候以兼夹证为主,证候呈现"虚进实渐"的演变规律,即实证-虚证-虚实夹杂证-虚衰证-衰竭证的病理过程.通过分析系统生物学在HIV/AIDS虚证及实证的应用,阐述了证候研究存在的问题,提出了对策及展望,旨在为相关研究提供参考.
HIV/AIDS is a complex and difficult disease,and no effective method of cure is available at present.HIV/AIDS syndrome is the core of syndrome differentiation.Studying the evolvement law and physical basis of the syndrome is a key link to exploring the essence of the syndrome,screening out drug targets,developing effective prescriptions and improving clinical efficacy.By combing the current status and prospect of HIV/AIDS syndrome studies and clinical practice,the author summarizes that HIV/AIDS syndrome is dominated by concurrent syndrome and presents an'excess-mix of excess and deficiency-deficiency'dynamic evolvement law.That is,the pathological process of excess syndrome-deficiency syndrome-deficiency and excess mixed with syndrome-deficiency and failure syndrome-failure syndrome.Besides,the paper analyzes the application of systems biology in HIV/AIDS deficiency syndrome and excess syndrome,elaborates on the problems in existing syndrome research,and puts forward countermeasures and prospects,with an aim to provide a reference for related research.

HIV/AIDSEvolvement law of syndromeImmunologic indicatorsSystems biologyProspect

宋夕元、马秀霞、孟鹏飞、刘梅君、金书情、唐洲、徐立然、郭会军

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河南中医药大学第一附属医院,郑州 450000

河南中医药大学,郑州 450046

河南省病毒性疾病中医药防治重点实验室,郑州 450000

HIV/AIDS 证候演变规律 免疫学指标 系统生物学 展望

国家"十三五"科技重大专项河南省中医药科学研究专项课题河南省自然科学基金项目河南省"双一流"创建学科中医学科学研究专项

2017ZX102055022021JDZY001232300420274HSRP-DFCTCM-2023-8-03

2024

中华中医药杂志
中华中医药学会

中华中医药杂志

CSTPCD北大核心
影响因子:1.135
ISSN:1673-1727
年,卷(期):2024.39(9)