Main effect traditional Chinese medicine based on uniform design screening and verification of Kanli Granules to improve chronic heart failure symptoms
Objective:Screening the main effect traditional Chinese medicine ingredient of anti-heart failure effects from the Kanli Granules,and then verify the efficacy of the filtering party.Methods:Abdominal aortic coarctation surgery was used to induce chronic heart failure of mice models,and DPSVT.05 data processing system was used to generate the U20(2010)table to group experiment for 10 flavor of Kanli Granules.Based on blood flow dynamics and muscle mesh calcium activity as screening indicators,a uniform design method was used to gradually return and analyze,so as to screen the main effect of traditional Chinese medicine.The model was used again for verification experiments,and the heart failure model was used to conduct a heart-colored Doppler,blood flow dynamic,and muscle mesh calcium activity testing,and verify the effect of the screened anti-chronic heart failure Chinese medicine.Results:When the dried medicinal herbs dosage of Astragali Radix,Aconiti Lateralis Radix Praeparate,Curcumae Rhizoma and Ophiopogonis Radix in Kanli Granules were 5.4,1.8,1.8,1.8 g/kg,respectively,the effect for improving chronic heart failure was the best.The screening results were accurate and reliable.Conclusion:Astragali Radix,Aconiti Lateralis Radix Praeparate,Curcumae Rhizoma and Ophiopogonis Radix are the main effect Chinese medicine in Kanli Granules to improve chronic heart failure.
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