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穿山甲的新药源研究策略

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穿山甲具消肿排脓、攻坚散结、通经下乳、疏风通络功效,被广泛应用于内、外、妇、儿各科,是众多传统经典名方的重要组成部分.由于多重因素的影响,穿山甲目前已成为濒危药材,被迫从《中华人民共和国药典》(一部)收载目录中移出,其入药将面临许多挑战和问题,也致使许多"国宝级"的中成药面临停产的困境,已严重影响中医药体系的完整性和中医药发展的可持续性.濒危药材作为中医药发展的战略资源,其代用品的研究意义重大.因此,文章以开展穿山甲独特药效评价及其物质基础研究为前提,依据其在中成药中的功效,研发替代品并进行系统性评价,同时考虑在人工繁育层面开展相应技术的应用,为后续穿山甲的研究和开发应用提供参考,同时也为濒危动物保护开辟新路径.
Research strategy of new drug source of pangolin
Pangolin possess notable medicinal properties,including reducing swelling,expelling pus,resolving hard masses,promoting lactation,and alleviating wind-dampness while improving meridian circulation.These therapeutic effects have led to their widespread use across various medical specialties,such as internal medicine,surgery,gynecology,and pediatrics,making them a key component of numerous classical Chinese medicinal formulas.However,due to various factors,pangolin have been classified as an endangered medicinal resource,resulting in their removal from the Pharmacopoeia of the People's Republic of China(Part I).This removal poses significant challenges for their use in human medicine and has forced many'national treasure'level Chinese patent medicines to the brink of discontinuation,thereby severely affecting the integrity of the traditional Chinese medicine(TCM)system and its sustainable development.As endangered medicinal resources are of strategic importance to the advancement of TCM,researching potential substitutes for pangolin scales is critically important.Therefore,this study is based on the evaluation of the unique pharmacological effects and material basis of pangolin.It aims to develop substitutes tailored to their roles in traditional Chinese medicines and systematically assess the efficacy and viability of these alternatives.Additionally,the study considers the application of relevant technologies in the context of artificial breeding,providing a reference for future research,development,and application of pangolin scales,while also opening new avenues for the conservation of endangered species.

PangolinMedicinal valueSubstitutesResearch strategy

王玉昆、周添慧、柳惠武、张爱荣、秦雪梅、高晓霞

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山西大学中医药现代研究中心,太原 030006

山西大学化学生物学与分子工程教育部重点实验室,太原 030006

地产中药功效物质研究与利用山西省重点实验室,太原 030006

山西广誉远国药有限公司,晋中 030800

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穿山甲 药用价值 替代品 研究策略

山西省中央引导地方科技发展资金项目名优晋药再开发山西省重点实验室地产中药功效物质研究与利用山西省重点实验室

YDZJSX2021C033202104010910001201605D111004

2024

中华中医药杂志
中华中医药学会

中华中医药杂志

CSTPCD北大核心
影响因子:1.135
ISSN:1673-1727
年,卷(期):2024.39(9)