Dicussion on the role of glucose metabolism reprogramming of macrophages in gastric 'inflammation-cancer transformation' based on the theory of spleen deficiency and blood stasis
The theory of gastric'inflammation-cancer transformation'asserts that spleen deficiency is intrinsic pathogenic factors,with blood stasis stemming from spleen deficiency,which serves as a significant pathological factor in the gastric'inflammation-cancer transformation'.Macrophages have been identified as the cell population within the tumor microenvironment with the highest capacity for glucose uptake and metabolism.They secrete inflammatory mediators and participate in the inflammatory response.During the transition from gastritis to gastric cancer,macrophages undergo metabolic changes primarily characterized by glucose metabolism reprogramming,which alters the phenotype and function of tumor-associated macrophages and promotes the'inflammation-cancer transformation'.This process is consistent with the pathogenesis theory of'spleen deficiency and blood stasis'.Based on the theory of'spleen deficiency and blood stasis'in traditional Chinese medicine,this paper analyzes its correlation with macrophage glucose metabolism reprogramming and the gastric'inflammation-cancer transformation'.This study is intended to provide a reference for the prevention and treatment of gastric'inflammation-cancer transformation'by traditional Chinese medicine.
Spleen deficiency and blood stasisMacrophagesGlucose metabolism reprogrammingGastric 'inflammation-cancer transformation'
NETL
NSTL
万方数据
