Analysis of the combination law of cough variant asthma syndrome elements and basic syndrome based on clinical investigation
Objective:To explore the distribution and combination law of cough variant asthma(CVA)syndrome elements and summarize the basic syndromes and their characteristics for disease differentiation.Methods:From January 1,2020 to January 31,2023,459 CVA patients were enrolled in outpatient clinics of 6 hospitals in different regions.The general information of the patients and information on the four diagnostic methods of traditional Chinese medicine were collected.Multivariate statistical analysis was performed using frequency and composition ratio statistical description,association rule analysis,latent structure analysis,etc..Results:A total of 16 pathogenic syndrome elements such as phlegm,yin deficiency,wind,and 7 disease location syndrome elements such as lung,surface,spleen,etc.,were obtained.In the form of syndrome combination,the most combinations of three syndromes(106 cases,24.7％),and the minimum single syndrome(39 cases,9.1％).Among the single pathogenic syndrome elements and the combination of disease location syndrome elements,phlegm and wind appeared most frequently,and their targets were mainly in the lung and the surface.Through the mutual reference of three statistical methods,the basic syndrome of CVA was determined when two or more conditions were met at the same time,namely,lung qi deficiency syndrome,lung yin deficiency syndrome,phlegm dampness syndrome,phlegm heat syndrome,and wind evil invading the lung syndrome.Conclusion:The main pathogenic syndrome elements of CVA patients are phlegm,yin deficiency,wind,and qi deficiency,and the main disease sites are the lungs and the surface.The pathological elements of CVA are complicated,and generally the disease location syndrome elements and multiple pathogenic syndrome elements are combined to cause the disease.Lung qi deficiency syndrome,lung yin deficiency syndrome,phlegm dampness syndrome,phlegm heat syndrome,and wind evil invading the lung syndrome may be the basic syndromes of CVA.
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