Study on the distribution pattern of dampness-turbidity syndrome and its correlation with clinical characteristics in 467 cases of diabetic kidney disease stage Ⅲ-Ⅳ
Objective:To investigate the distribution pattern of dampness-turbidity syndrome of diabetic kidney disease(DKD)stage Ⅲ-Ⅳ patients and to analyze its correlation with clinical characteristics.Methods:This study collected data on traditional Chinese medicine(TCM)syndromes,general information,medical history,examination indices,and the proportion and integration of deficiency syndromes from 467 patients with DKD stages Ⅲ-Ⅳ by clinical cross-sectional study design.Then,using correlation analysis and logistic regression,we investigated the distribution of dampness-turbidity syndrome in DKD and its association with clinical features.Results:Patients with dampness-turbidity syndrome accounted for 56.7％of those with DKD.The prevalence of dampness-turbidity syndrome was significantly higher in DKD Stage Ⅳ than in Stage Ⅲ(P＜0.05).Additionally,the severity of dampness-turbidity syndrome was relatively higher(P＜0.05).Compared to the non-dampness-turbidity syndrome group,patients with dampness-turbidity syndrome had a higher prevalence of hypertension,hyperlipidemia,and hyperuricemia(P＜0.05).They also exhibited higher levels of FPG,HbA1c,K,P,Scr,BUN,UA,TG,PRO,and ACR(P＜0.05),while having lower levels of HGB and eGFR(P＜0.05).Furthermore,the proportion and severity of deficiency syndrome were higher in this group(P＜0.05).Correlation analysis revealed that the score of dampness-turbidity syndrome in DKD patients was positively correlated with the duration of type 2 diabetes,as well as levels of P,Scr,BUN,UA,PRO,ACR,24-hour UTP,and scores of qi-deficiency and yang-deficiency syndromes(P＜0.05).Multivariate logistic regression showed that P,Scr,UA,and scores of qi-deficiency and yang-deficiency syndromes were positively correlated with dampness-turbidity syndrome(P＜0.05),while eGFR was negatively correlated with dampness-turbidity syndrome(P＜0.05).Conclusion:Dampness-turbidity syndrome commonly exists in patients with DKD,which promotes the development of disease to some extent.Moreover,accumulation of metabolic products such as P,Scr,UA may be objective indicators reflecting dampness-turbidity syndrome in patients with DKD.
NETL
NSTL
万方数据
