基于中西医临床病证特点的子宫腺肌病动物模型分析
Analysis of animal model of adenomyosis based on the characteristics of clinical evidence in Chinese and Western medicine
井贺云 1孟驿佳 1王泽茜 1王媛 1苗明三1
作者信息
摘要
子宫腺肌病(AM)是临床上十分常见的一种女性疾病,对患者身心健康造成了极大的威胁.以"子宫腺肌病"为主题,设置年限为"2002-2022",通过对CKNI、万方、维普网等近20年的动物模型进行分析,归纳各造模方法与中、西医临床病证的吻合程度,结果显示小鼠口服他莫昔芬法AM模型中西医临床吻合度较高,且具有操作简便、成本较低、成功率高等优点,是目前应用普遍、较为理想的动物模型.目前AM动物模型以西医的疾病模型为主,符合中医病证特点的模型少见.建立符合中医病证特点的模型是探寻中医中药防治的基础,因此构建中西医临床病证结合的动物模型是目前研究的首要任务.
Abstract
Adenomyosis is a very common clinical female disease that poses a great threat to the physical and mental health of patients.With the theme of'adenomyosis'and the period of'2002-2022',we analyzed the animal models from CKN1,Wanfang,and VIP in the past 20 years,and summarized the degree of agreement between each modeling method and the clinical conditions in Chinese and Western medicine.The results showed that the AM model of oral tamoxifen in mice has a high degree of clinical compatibility between Chinese and Western medicine,and has the advantages of simple operation,low cost and high success rate,which makes it a commonly used and ideal animal model at present.Currently,AM animal models are dominated by disease models of western medicine,and models that match the characteristics of Chinese medical conditions are rare.The establishment of a model that meets the characteristics of Chinese medicine diseases is the basis for exploring the prevention and treatment of Chinese medicine,so the construction of an animal model that combines traditional Chinese and Western medicine clinical diseases is the first task of the current research.
关键词
子宫腺肌病/动物模型/中西医临床病证特点/诊断标准Key words
Adenomyosis/Animal model/Characteristics of clinical symptoms of traditional Chinese and Western medicine/Diagnostic criteria引用本文复制引用
基金项目
河南省科技攻关项目(212102310351)
河南省中医药科学研究专项课题(20-21ZYZD02)
出版年
2024
国家科技期刊平台
NSTL
万方数据