基于"主客交-络病"理论探析糖尿病微血管区域免疫调节稳态
Study on the homeostasis of microvascular immunomodulation in diabetes mellitus based on the theory of'host-guest intercourse-collaterals disease'
陈彦旭 1金智生1
作者信息
摘要
络脉既是血气汇集之所,也是疾病传变的中心环节.因其聚、流、通、化的特殊生理特性,衍生出虚、瘀、痰、毒的致病机制.糖尿病微血管区域免疫调节失衡隶属中医"络病"范畴,乃脏腑受制,正虚邪聚,结滞酿毒,积毒不化,毒蕴络脉,终至络损."主客交"泛指机体正虚不受(气血精津亏耗),邪毒胶结,而致主客交浑血络.免疫调节是现代医学概念,可分为机体自稳、防御、监视3种状态,共同起到维系、恢复机体内外微环境免疫稳态的作用.免疫调控失衡与主客交致病机理类似,异常的免疫反应是正虚不受、邪毒胶结的微观表现;络损是毒蕴结滞、侵注血络的生物学基础.而主胜客又能从整体角度呈现免疫调节功能,最终使糖尿病微血管区域达到"正气存内,邪不可干"的免疫衡稳状态.从"主客交-络病"理论探析糖尿病微血管区域免疫调节稳态的生物学内涵并诠释病机内涵,以期为糖尿病微血管区域病变的发病机制、诊疗策略提供思路和理论依据.
Abstract
Collaterals are not only the gathering place of blood gas,but also the central link of disease transmission.Because of its special physiological characteristics of accumulation,flow,communication and transformation,it derives the pathogenic mechanism of deficiency,blood stasis,phlegm and toxin.The imbalance of immune regulation in diabetic microvascular region belongs to the category of'collateral disease'in traditional Chinese medicine,which is controlled by viscera,accumulation of positive and deficient pathogen,stagnation of toxin,accumulation of poison,accumulation of poison in collaterals,and finally collateral damage.'Host-guest intercourse'generally refers to the deficiency of the body(loss of qi and blood essence),evil poison cementation,resulting in muddy blood collaterals between the host and the guest.Immune regulation is a modern medical concept,which can be divided into three states:self-stabilization,defense and surveillance,which play a role in maintaining and restoring the immune homeostasis of the microenvironment inside and outside the body.The imbalance of immune regulation is similar to the pathogenic mechanism of host-guest intercourse,the abnormal immune response is the microscopic manifestation of positive deficiency and evil toxin cementation,and collateral damage is the biological basis of toxin accumulation and stagnation and invasion of blood collaterals.On the other hand,the main winner can present the immune regulation function from the overall point of view,and finally make the diabetic microvascular region reach the immune balance state of'positive qi is stored,evil can not be dried'.Based on the theory of'host-guest intercourse-collateral disease',this paper probes into the biological connotation of diabetic microvascular regional immune regulation homeostasis and interprets the pathogenesis,in order to provide ideas and theoretical basis for the pathogenesis,diagnosis and treatment of diabetic microvascular regional disease.
关键词
主客交/络病/吴又可/糖尿病微血管/免疫调节Key words
Host-guest intercourse/Collateral disease/WU Youke/Diabetic microvascular/Immune regulation引用本文复制引用
出版年
2024
NETL
NSTL
万方数据