Study on the homeostasis of microvascular immunomodulation in diabetes mellitus based on the theory of'host-guest intercourse-collaterals disease'
Collaterals are not only the gathering place of blood gas,but also the central link of disease transmission.Because of its special physiological characteristics of accumulation,flow,communication and transformation,it derives the pathogenic mechanism of deficiency,blood stasis,phlegm and toxin.The imbalance of immune regulation in diabetic microvascular region belongs to the category of'collateral disease'in traditional Chinese medicine,which is controlled by viscera,accumulation of positive and deficient pathogen,stagnation of toxin,accumulation of poison,accumulation of poison in collaterals,and finally collateral damage.'Host-guest intercourse'generally refers to the deficiency of the body(loss of qi and blood essence),evil poison cementation,resulting in muddy blood collaterals between the host and the guest.Immune regulation is a modern medical concept,which can be divided into three states:self-stabilization,defense and surveillance,which play a role in maintaining and restoring the immune homeostasis of the microenvironment inside and outside the body.The imbalance of immune regulation is similar to the pathogenic mechanism of host-guest intercourse,the abnormal immune response is the microscopic manifestation of positive deficiency and evil toxin cementation,and collateral damage is the biological basis of toxin accumulation and stagnation and invasion of blood collaterals.On the other hand,the main winner can present the immune regulation function from the overall point of view,and finally make the diabetic microvascular region reach the immune balance state of'positive qi is stored,evil can not be dried'.Based on the theory of'host-guest intercourse-collateral disease',this paper probes into the biological connotation of diabetic microvascular regional immune regulation homeostasis and interprets the pathogenesis,in order to provide ideas and theoretical basis for the pathogenesis,diagnosis and treatment of diabetic microvascular regional disease.
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