基于"脾为之卫"理论靶向肠道菌群探讨类风湿关节炎的防治
Study on the prevention and treatment of rheumatoid arthritis based on the theory of'spleen as the guardian'targeting intestinal microbiota
刘源 1姜萍1
作者信息
- 1. 山东中医药大学第一临床医学院,济南 250300
- 折叠
摘要
类风湿关节炎(RA)是一种慢性炎症性自身免疫性疾病,病程较长,致残率高.现代研究发现肠道菌群紊乱可能是RA发病的促进因素,但其机制尚不明确.中医学认为"脾为之卫"功能失常是RA发病的核心病机.而肠道菌群的调节作用与"脾为之卫"功能具有相似性.因此文章基于"脾为之卫"理论探讨脾、肠道菌群、RA三者的相关性,为靶向肠道菌群治疗RA提供理论依据,并从肠道微生物的角度丰富从脾论治RA的科学内涵.
Abstract
Rheumatoid arthritis(RA)is a chronic inflammatory autoimmune disease with a prolonged course and a high disability rate.Modern research has found that intestinal microbiota dysbiosis may be a contributing factor in the pathogenesis of RA,but the underlying mechanism is not yet fully understood.Traditional Chinese medicine considers that the dysfunction of the'spleen as the guardian'function is the core pathogenesis of RA.The regulatory role of the intestinal microbiota is similar to the'spleen as the guardian'function.Therefore,this paper explores the relationship among the spleen,intestinal microbiota,and RA based on the'spleen as the guardian'theory,providing a theoretical basis for targeting the intestinal microbiota in the treatment of RA,and enriching the scientific connotation of treating RA from the perspective of the spleen.
关键词
脾为之卫/脾失之卫/肠道菌群/类风湿关节炎/中草药Key words
Spleen as the guardian/Spleen's defense is lost/Intestinal microbiota/Rheumatoid arthritis(RA)/Traditional Chinese herbal medicine引用本文复制引用
基金项目
国家自然科学基金项目(82274481)
国家自然科学基金项目(81874449)
国家中医药管理局科技司共建科技项目(GZY-KJS-SD-2023-041)
山东省自然科学基金项目(ZR2022LZY004)
齐鲁张氏风湿骨病中医药特色技术项目(鲁卫函[2022]93号)
出版年
2024
NETL
NSTL
万方数据