探究细胞力学响应视角下的针刺腧穴局部启动机制
Investigation on the local initiation mechanism of acupuncture acupoints under the perspective of cellular mechanical response
刘怀全 1杨诗力 1陈波 1唐易 1王丹 1李洁 1张馨艳1
作者信息
摘要
针刺作为一种传统中医外治法,其本质上是一种机械性物理刺激.尽管针刺在诸多疾病的治疗中得以广泛应用,且疗效卓著,但其深层次的效应机制仍未完全明晰.目前,关于针刺腧穴效应机制的研究多聚焦于靶器官层面,而从腧穴局部角度展开的探究尚显不足.随着细胞力学研究的不断深入,学者们逐渐关注到细胞作为机体结构与功能的基本单位,在感受与响应力学信号中扮演着关键角色.细胞主要通过细胞外基质、细胞膜上力学敏感受体、细胞骨架以及核骨架等结构感受和响应细胞力学信号.鉴于针刺腧穴所产生的机械刺激也会对这些力学感受器产生一定的影响,文章将从细胞力学响应视角探究针刺腧穴局部启动的机制.
Abstract
Acupuncture,as a traditional Chinese medicine external treatment method,is essentially a mechanical physical stimulation.Although acupuncture has been widely used in the treatment of many diseases with outstanding efficacy,its deep-rooted effect mechanism is still not fully understood.Currently,research on the effect mechanism of acupuncture points focuses on the target organ level,while the investigation from the local perspective of acupuncture points is still insufficient.With the continuous deepening of cellular mechanics research,scholars have gradually focused on the fact that cells,as the basic unit of organism structure and function,play a key role in sensing and responding to mechanical signals.Cells sense and respond to cellular mechanical signals primarily through structures such as the extracellular matrix,mechanosensitive receptors on the cell membrane,the cytoskeleton,and the nucleoskeleton.Given that the mechanical stimulation produced by acupuncture points will also have some effects on these mechanoreceptors,this paper will explore the mechanism of local initiation of acupuncture acupuncture points under the perspective of cellular mechanical response.
关键词
细胞力学响应/物理刺激/针刺/腧穴/局部启动Key words
Cellular mechanical response/Physical stimulation/Acupuncture/Acupoints/Local initiation引用本文复制引用
基金项目
国家自然科学基金项目(82360976)
贵州中医药大学研究生教育创新计划项目(YCXZRB202211)
出版年
2024
国家科技期刊平台
NSTL
万方数据