Retrospective study of heart and spleen combined therapy in treatment of heart failure with improved ejection fraction
Objective:To evaluate the clinical efficacy of heart and spleen combined therapy in treatment of heart failure with improved ejection fraction(HFimpEF),to review the characteristics of traditional Chinese medicine(TCM)syndromes in HFimpEF,and to analyze the risk factors for rehospitalization within one year.Methods:Case data of HFimpEF patients were collected,and based on oral administration of the heart and spleen treatment TCM formula for ≥ 10 days during hospitalization,patients were divided into a TCM group(235 cases)and a control group(213 cases).The differences in TCM syndromes,NYHA cardiac function classification,brain natriuretic peptide(BNP),echocardiography parameters,weight,and the rate of rehospitalization within one year were statistically analyzed.Logistic regression was used to explore the risk factors for rehospitalization within one year.Results:A total of 448 cases were included,with 142 rehospitalization events within one year.The top three TCM syndromes were phlegm turbidity obstruction syndrome(29.9％),qi and yin deficiency syndrome(16.5％),and qi deficiency and blood stasis syndrome(16.1％).Factors affecting rehospitalization in HFimpEF included TCM treatment(OR=0.447),hyperuricemia(OR=1.800),dyslipidemia(OR=1.918),type 2 diabetes(OR=1.881),and stroke(OR=2.395).The effects of the heart and spleen treatment TCM formula:Compared to the control group,the TCM group showed significant improvements in NYHA cardiac function classification,a significant reduction in BNP and the rate of rehospitalization within one year(P＜0.01),and an increase in left ventricular ejection fraction(LVEF)(P＜0.05).Conclusion:The main TCM syndrome in HFimpEF is phlegm turbidity obstruction syndrome.Heart-spleen combined treatment with TCM can reduce the risk of re-hospitalization in HFimpEF patients,significantly improve the cardiac function,significantly reduce BNP,and increase LVEF.A history of hyperuricemia,dyslipidemia,type 2 diabetes,and stroke increases the risk of re-hospitalization in HFimpEF patients.
Heart failure with improved ejection fraction(HFimpEF)Left ventricular ejection fractionHeart-spleen-together approachRegression analysisPropensity score match
NETL
NSTL
万方数据
