Observation on the therapeutic effect of Loudan Lifei Granules on acute exacerbation of chronic obstructive pulmonary disease patients with phlegm-heat obstructing lung syndrome
Objective:To observe the effects of Loudan Lifei Granules on clinical symptoms,quality of life,and inflammation indices in acute exacerbation of chronic obstructive pulmonary disease(AECOPD)patients with phlegm-heat obstructing lung syndrome.Methods:A randomized,double-blind,placebo-controlled study was conducted on 72 AECOPD patients,who were randomly divided into a treatment group and a control group,with 36 patients in each group.The treatment group was given oral administration of Loudan Lifei Granules,while the control group was given placebo of Loudan Lifei Granules.Both groups received continuous medication for 7 days.Observe the improvement of clinical efficacy,traditional Chinese medicine syndrome scores,lung function,and inflammation indices in two groups of patients.Results:After 7 days of treatment,the CAT scores of patients in the treatment group were significantly lower than those in the control group(P＜0.05);the control rate of the treatment group was 65.63％(21/32),significantly higher than 36.67％(11/30)of the control group(P＜0.05).In terms of improving the EXACT-PRO scale,the treatment group was significantly better than the control group,and the difference was statistically significant(P＜0.01);the scores of cough,expectoration,wheezing,chest tightness,irritability,and fatigue in the treatment group were significantly lower than those in the control group in terms of single TCM syndrome(P＜0.05).In terms of lung function,patients showed a certain degree of improvement in FEV,and FVC after treatment,but there was no statistically significant difference between the two groups.After treatment the levels of peripheral blood inflammation index TNF-α,IL-17A and IL-6 in treatment group were significantly lower than the control group(P＜0.05).Conclusion:Loudan Lifei Granules can improve the clinical symptoms of AECOPD patients with phlegm-heat obstructing lung syndrome,reduce the impact of acute exacerbation on lung function and inflammatory reactions.
Loudan Lifei GranulesAcute exacerbation of chronic obstructive pulmonary disease(AECOPD)Clinical symptomsQuality of lifeInflammation index
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