中药透皮给药治疗乳腺增生症动物模型研究进展与展望
Research progress and prospect of transdermal administration of traditional Chinese medicine in the treatment of breast hyperplasia animal models
于旭峰 1魏云霞 2王晓钰 2乔明琦1
作者信息
- 1. 山东中医药大学中医学院,济南 250355
- 2. 山东中医药大学药学院,济南 250355
- 折叠
摘要
乳腺增生症是一种与内分泌功能紊乱密切相关的既非炎症又非肿瘤的乳腺增生性病变.目前该病的概念、分类、诊断和治疗等存在诸多分歧.中药透皮给药治疗乳腺增生症在促透皮吸收方法、中药透皮成分以及透皮吸收评价方法中存在诸多问题.根据临床疾病模拟设计的动物模型及评价方法不统一,同时具有一定的局限.目前很难在同一动物模型上评价中药透皮吸收作用及药效,因此,寻找具有多因素致病的乳腺增生症动物模型对于开发能有效防治乳腺增生症的新药具有重要的理论意义和现实意义.
Abstract
Mammary gland hyperplasia(MGH)is a kind of breast hyperplasia that is closely related to endocrine dysfunction and is neither inflammatory nor tumor.At present,there are many differences in the concept,classification,diagnosis and treatment of the disease.There are many problems in the method of promoting transdermal absorption,the transdermal composition of traditional Chinese medicine and the evaluation method of transdermal absorption in the treatment of MGH by transdermal administration of traditional Chinese medicine.Animal models and evaluation methods designed based on clinical disease simulation are not uniform and have certain limitations.At present,it is difficult to evaluate the transdermal absorption and efficacy of traditional Chinese medicines in the same animal model.Therefore,finding an animal model of MGH with multi-factor pathogenesis has important theoretical and practical significance for the development of new drugs to effectively prevent and treat MGH.
关键词
中药/透皮给药/透皮吸收/乳腺增生症/动物模型/进展Key words
Traditional Chinese medicine/Percutaneous administration/Transdermal absorption/Mammary gland hyperplasia(MGH)/Animal model/Progress引用本文复制引用
出版年
2024
NETL
NSTL
万方数据