Irritable bowel syndrome(IBS)is a prevalent functional bowel disease.Research suggests that the imbalance of intestinal flora is one of its fundamental pathogenesis.The associated symptoms of IBS are also observed when fecal microbiota is transplanted into germ-free animals.Thus,animal models of IBS based on humanized intestinal flora are receiving increasing attention.This paper reviewed the methods of constructing the animal models of IBS based on humanized intestinal flora,and analyzed the research progress of the pathological mechanism and therapeutic mechanism of IBS based on this model in recent years.Additionally,this paper also proposed the research strategy for constructing the animal model of humanized intestinal flora based on traditional Chinese medicine syndrome differentiation,to provide a theoretical basis for the prevention and treatment of IBS and the study of traditional Chinese medicine based on the IBS animal model of humanized intestinal flora.
Irritable bowel syndrome(IBS)Intestinal floraHuman flora-associatedGerm-free mouseTraditional Chinese medicineAnimal modelProgressStrategy
NETL
NSTL
万方数据
