Metabolic-associated fatty liver disease(MAFLD)has become the most common chronic liver disease in the world,which can progress to liver fibrosis or cirrhosis,seriously threatening people's health,but there is no specific drug treatment yet.According to research reports,the classic Chinese medicine formula Dachaihu Decoction is effective in the treatment of MAFLD.In this paper,we summarize and generalize the literature and find that the mechanism of Dachaihu Decoction in the treatment of MAFLD is mainly related to the improvement of insulin resistance,the promotion of mitochondrial oxidation function,the promotion of mitochondrial autophagy,and the regulation of the intestinal bacterial flora,and so on.This paper discusses the treatment of MAFLD by Dachaihu Decoction from three aspects:basic formula theory,clinical research and basic research,aiming to provide reference value for the clinical application of Dachaihu Decoction in the treatment of MAFLD.
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