Exploring on the causal link between gut microbiota and lower respiratory tract infections based on the'tnterior-exterior relationship between the lung and large intestine':A two-sample Mendelian randomization study
Objective:To investigate the causal link between 211 gut microbiota species and lower respiratory tract infections(LRTI)using a two-sample Mendelian randomization(MR)approach.Methods:A two-sample MR analysis was conducted to explore the relationship between gut microbiota and five types of LRTI,including acute bronchitis,acute bronchiolitis,bronchiectasis,bacterial pneumonia and influenza pneumonia.For MR analysis,the inverse variance weighted(IVW)method was used as the primary analytical tool,with heterogeneity and pleiotropy tested to ensure robustness.Additionally,leave-one-out analysis was performed to assess the stability of the MR results.Results:There were 15 microbial taxa potentially associated with LRTI,including three taxa related to acute bronchitis,three to acute bronchiolitis,three to bronchiectasis,three to bacterial pneumonia,and three to influenza pneumonia.Conclusion:This study provides evidence of a causal link between gut microbiota and LRTI,offering new insights into the prevention of LRTI mediated by gut microbiota.
Lower respiratory tract infections(LRTI)Gut microbiotaMendelian randomization(MR)Causal linkTnterior-exterior relationship between the lung and large intestine
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