Investigations and analysis of the abnormalities of urination and defecation function in patients with multiple sclerosis and neuromyelitis optica spectrum disorders
Objective:To investigate the link between'brain-kidney-bowel/bladder'by investigating the abnormalities of urination and defecation function in patients with multiple sclerosis(MS)and neuromyelitis optica spectrum disorder(NMOSD).Methods:A total of 204 patients with MS and NMOSD who attended the Department of Traditional Chinese Medicine,Beijing Tiantan Hospital,Capital Medical University from November 2023 to May 2024 were enrolled,and demographic and clinical data,clinical characteristics,imaging findings,diarrhea,and quality of life were collected and counted using outpatient face-to-face interviews,telephone calls,and electronic questionnaires in conjunction with the information from the medical records.Results:A total of 119(58.3％)of the 204 patients had diastasis,including 75(63.0％)cases of constipation and dyspareunia,8(6.7％)cases of fecal incontinence,40(33.6％)cases of waiting for urine and delayed micturition,71(59.7％)cases of urinary frequency and urgency and incontinence,while 47(39.5％)of the patients had at least one bladder and one bowel function symptoms coexisted.A total of 77(64.7％)of the patients with the abnormalities of urination and defecation function were of the liver and kidney yin deficiency type.Logistic stepwise regression analysis showed that lesions in the cerebrum,medulla oblongata,cervical spinal cord,and thoracic cord were the independent risk factors leading to the development of the abnormality of defecation(P＜0.01,P＜0.05);age,and the presence of a lesion in the cerebrum,cerebellum,medulla oblongata,cervical spinal cord,and thoracic cord were independent risk factors for the development of the abnormality of urination(P＜0.01,P＜0.05).Conclusion:The abnormalities of urination and defecation function in MS and NMOSD patients is associated with kidney deficiency,and patients with brain and spinal cord lesions are more likely to develop the abnormalities of urination and defecation function.
Multiple sclerosis(MS)Neuromyelitis optica spectrum disorder(NMOSD)Abnormalities of urination and defecation functionLogistic regression analysisCentral nervous system diseaseSyndromeBrain-kidney-bowel/bladderCross sectional survey
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