针刺改善非痴呆型血管性认知障碍患者相关认知域:一项多中心随机对照研究的二次分析
Secondary analysis of a multi-center randomized controlled trial on acupuncture for improving cognitive domains in patients with vascular cognitive impairment no dementia
曹燕 1赵吉平 1汪露 2闫超群 1杨静雯 2石广霞 2肖凌勇 3刘存志2
作者信息
- 1. 北京中医药大学东直门医院,北京 100700
- 2. 北京中医药大学针灸推拿学院,北京 100029
- 3. 天津中医药大学第一附属医院针灸部,天津 300380;国家中医针灸临床医学研究中心,天津 300380
- 折叠
摘要
目的:评价针刺改善非痴呆型血管性认知障碍(VCIND)患者不同认知域的临床疗效.方法:216例VCIND患者以1∶1的比例随机分配至针刺组和药物组,对患者治疗前、12周治疗后和24周随访时阿尔茨海默病评估量表的记忆、执行、语言和注意力4个认知域进行分析;按照受教育年限分为高等教育组和非高等教育组,评估教育对4个认知域评分的影响.结果:与药物组比较,针刺组治疗后记忆和注意力评分显著改善(P＜0.05),随访时执行评分显著改善(P＜0.05).接受高等教育组中针刺组治疗后注意力评分显著优于药物组(P＜0.01);非高等教育组中针刺组治疗后和随访时执行评分均显著优于药物组(P＜0.05).结论:针刺能够显著改善患者记忆、注意力和执行功能.在接受高等教育的人群中,针刺对注意力的改善效果更好,而在未接受高等教育的人群中,针刺对执行功能的改善效果更好.
Abstract
Objective:To evaluate the clinical efficacy of acupuncture in improving different cognitive domains in patients with vascular cognitive impairment no dementia(VCIND).Methods:A total of 216 VCIND patients were randomly assigned to an acupuncture group and a medication group in a 1∶1 ratio.The four cognitive domains of memory,executive function,language,and attention were analyzed using the Alzheimer's Disease Assessment Scale before treatment,at 12 weeks post-treatment,and during the 24-week follow-up.Based on years of education,patients were further divided into a higher education group and a non-higher education group to assess the influence of education on these four cognitive domains.Results:Compared to the medication group,the acupuncture group demonstrated significant improvements in memory and attention scores post-treatment(P＜0.05),and significant improvements in executive function scores during follow-up(P＜0.05).In the higher education group,attention scores were superior in the acupuncture group compared to the medication group(P＜0.01).In the non-higher education group,executive function scores were better in the acupuncture group both post-treatment and during follow-up than that in medication group(P＜0.05).Conclusion:Acupuncture significantly improves memory,attention,and executive function among patients.Among those with higher education,acupuncture shows a more pronounced effect on improving attention,while among those with non-higher education,acupuncture exhibits a superior effect on enhancing executive function.
关键词
针刺/非痴呆型血管性认知障碍/认知域/执行/记忆/语言/注意力/教育Key words
Acupuncture/Vascular cognitive impairment no dementia(VCIND)/Cognitive domain/Executive function/Memory/Language/Attention/Education引用本文复制引用
出版年
2024
NETL
NSTL
万方数据