OBJECTIVE To update recent progress in toxic mechanism of Tripterygium wilfordii,discuss relationship between its toxicity and constituents,and provide a guidance for rational drug use in clinical practice.METHODS By referring to recent literatures at home and abroad systematically,toxic mechanism of Tripterygium wilfordii was reviewed.RESULTS Toxicity of tripterygium wilfordii was involved in multiple organs and systems,and toxic components were also considered as effective components.Research on toxic mechanism of Tripterygium wilfordii is helpful to develop preparations of high efficiency and low toxicity,and provide a guidance for rational drug use in clinical practice.CONCLUSION Toxic mechanism of Tripterygium wilfordii has become a focus,and some progresses have been achieved.However,studies on acion mechanism are still not complete and systemic for Tripterygium wilfordii due to complexity of its chemical components and integrity of TCM pharmacology,and further studies are still needed.
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