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金线莲苷研究进展

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通过查阅、整理、分析和总结相关文献资料,了解到:从3种开唇兰属植物中分离到包括金线莲苷在内的8种丁酸衍生物葡萄糖苷;金线莲苷具有降血糖、降血脂、保肝护肝和改善骨质疏松等的作用;人工合成金线莲苷方法包括化学方法,化学方法和酶促法相结合两种方法.金线莲苷药理活性确切,但其自然资源匮乏,人工合成金线莲苷得率低、条件难控制,因此,今后将围绕提高开唇兰植物中金线莲苷的提取率,明确金线莲苷体内的具体作用机制,并将其用于临床研究,明晰金线莲苷的生物合成途径展开.
Recent advances in kinsenoside studies
Related references were researched, classified and analyzed.Eight glycosides of butanoic acid derivatives were isolated and identified.Kinsenoside had obvious antihyperglycemic, antihypersis and hepatoprotective activities, and also obvious bioactivities of preventing bone loss and anti inflammatory reactions.Its anticancer and antibacterial activities were not obvious.The artificial synthetic methods included chemical synthesis and chemical synthesis combined with enzymatic synthesis.Because of lacking natural recourses of kinsenoside and difficulties in artificial synthesis, future study will focus on improving extraction yield of kinsenosied from Anoectochilus plants, studying on specific action mechanism of kinsenoside, and interpreting the biosynthesis pathways.

kinsenosideglucosides of butanoic acid derivativespharmacological activityartificial synthesiskinsenoside biosynthesis

王建栋、王红珍、张爱莲、邵清松

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浙江农林大学亚热带森林国家重点实验室培育基地,浙江杭州311300

金线莲苷 丁酸衍生物葡萄糖苷 药理活性 人工合成 生物合成

浙江省自然科学基金浙江农林大科研发展基金人才启动项目

LY14H2800082014FR062

2015

中国医院药学杂志
中国药学会

中国医院药学杂志

CSTPCDCSCD北大核心
影响因子:1.198
ISSN:1001-5213
年,卷(期):2015.35(19)
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