三清降糖分散片的处方优化
Preparation and optimization of Sanqingjiangtang dispersible tablets
吕立勋 1赵琳琳 1李唐棣 1赵利刚1
作者信息
- 1. 华北理工大学药学院,唐山市新型药物制剂与释药技术重点实验室,河北唐山063000
- 折叠
摘要
目的:制备三清降糖分散片并优化其处方工艺.方法:以崩解时限为指标,对填充剂、崩解剂类型进行单因素考察,并通过正交试验优化;高效液相色谱(HPLC)法测定优选处方所制分散片黄芩苷含量和溶出度.结果:优化处方为30％微晶纤维素、20％预胶化淀粉作为填充剂,6％交联聚维酮作为崩解剂,2％微粉硅胶作为润滑剂.按优化处方粉末直接压片制备的三清降糖分散片3 min内分散均匀,15 min溶出度达到90％以上.结论:按优选处方制得的三清降糖分散片,遇水崩解迅速、分散均匀性好,质量可控.
Abstract
OBJECTIVE To prepare Sanqingjiangtang dispersible tablets and optimize its formulation technology.METHODS Distribution time was used as the index,single factor test was conducted for the types of filler and disintegrating agent.The indexes were optimized by orthogonal experiment.The tablet quality by optimized formulation was detected,and the content and dissolution rate of baicalin were determined by HPLC.RFSULTS The optimized formulation was composed of 30％ MCC and 20％ α-starch as fillers,6％ PVPP as disintegrants,micro-silica gel 2％.The distribution homogeneity was good at 3 min.The accumulative dissolution rate was more than 90％ at 15 min.CONCLUSION Sanqingjiangtang dispersible tablet has a rapid disintegration,a good distribution homogeneity and controllable quality.
关键词
三清降糖分散片/处方工艺/黄芩苷/HPLC/溶出度Key words
Sanqingjiangtang dispersible tablets/formulation technology/baicalin/HPLC/dissolution rate引用本文复制引用
基金项目
2014年河北省中医药管理局科技支撑项目(2014060)
出版年
2017
NETL
NSTL
维普
万方数据