Analysis of the correlation between serum through concentration of vancomycin and its efficacy and neph-rotoxicity in Tibetan patients
OBJECTIVE To investigate the correlation between the serum trough concentration of vancomycin and its thera-peutic effect and nephrotoxicity in Tibetan patients with infection,so as to provide reference for the individualized medication of vancomycin in Tibetan patients.METHODS Tibetan patients who were treated with vancomycin and received treatment drug monitoring in Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region from April 2020 to September 2022 were consecutively enrolled.The patients were divided into groups according to the serum trough concentration monitoring results,and the treatment effect of infection and the risk of nephrotoxicity were compared.RESULTS A total of 88 patients were enrolled.Totally 88 cases had treatment effect evaluation results,and renal toxicity evaluation results were available in 81 cases.The results of univariate and multivariate analyses showed that serum trough concentration lower than 10 mg·L-1 had no statisti-cally significant effect on the efficacy of infection treatment,and serum trough concentration higher than 20 mg·L-1 had no statisti-cally significant effect on the risk of nephrotoxicity in Tibetan patients.CONCLUSION The current serum trough concentration range of vancomycin(10-20 mg·L-1)may not be suitable for monitoring the blood concentration of vancomycin in Tibetan popu-lation.Population pharmacokinetics studies in Tibetan population are needed to further explore the suitable trough concentration range of vancomycin.
NETL
NSTL
万方数据
维普
