A systematic review and Meta-analysis of sodium-glucose cotransporter-2 inhibitors(SGLT-2I)on renal outcomes in type 2 diabetic patients
OBJECTIVE To investigate the effect of sodium glucose cotransporter 2 inhibitor on kidney in patients with dia-betes through systematic review,and to provide evidence for clinical medication.METHODS CNKI,Wanfang,VIP,China Biomedical Literature Database,Ovid Medline,Ovid EMBASE and CENTRAL database were searched systematically from inception to November 9,2022.Patients with a definite diagnosis of type 2 diabetes were included and eligible randomized con-trolled trials were evaluated for quality and data extraction.Data were analyzed using Stata16 MP.RESULTS A total of 12 stud-ies were included,including 8 randomized controlled trials and 4 pre-determined subgroup studies with renal outcomes,involving 60 767 patients.The systematic review showed that treatment with SGLT-2I significantly improved the risk of complex renal out-comes from renal deterioration,end-stage renal disease,or renal death in patients with diabetes compared with placebo RR=0.63,95％ CI(0.57-0.69),and this benefit persisted in patients with chronic renal disease.CONCLUSION SGLT-2I has sig-nificant renal protection effect in diabetic patients.
NETL
NSTL
万方数据
维普
