The use of antibiotics in children was evaluated based on different indexes
OBJECTIVE To evaluate the use of antibiotics in children based on different indexes,in order to provide reference for clinical rational drug use evaluation.METHODS A retrospective analysis was conducted to select 5 984 medical records from the Children's Hospital Affiliated to Zhengzhou University from April 2022 to September 2022.Basic data and the use of antibiotics were extracted,and the utilization rate,drug purpose,treatment days,treatment duration and daily prescription dose of antibiotics were statistically analyzed.RESULTS Among 5 984 medical records,the utilization rate of antibiotics was 41.29％,among which,the utilization rate of antibiotics was 81.37％in children from 0 to 28 days,and 92.43％in children hospitalized for more than 30 days.The top three antibacterial drugs used frequently were the third generation,the second generation and the first generation cephalosporins,with utilization rates of 42.78％,15.52％and 10.95％,respectively.There were great differences in clinical indications of different types of antibiotics.The first generation of cephalosporins(327/335,97.61％)and the second gen-eration of cephalosporins(220/475,46.32％)were mainly used for perioperative prophylactic use.Macrolides(176/187,94.16％),penicillins(47/53,88.68％)and third-generation cephalosporins(1 119/1 309,85.49％)were mainly used for com-munity acquired infections.Treatment days per 100 person days were 48.16 DOTs,treatment duration per 100 person days was 40.87 LOTs,DOT/LOT was 1.18,treatment days per 100 person-days and treatment duration per 100 person days were signifi-cantly different among different ages,length of stay and departments(P＜0.01);The prescription daily dose increased with age,The prescription daily dose of children older than 10 years was close to adult DDD.The ratio of prescription daily dose of children older than 10 years and children aged 0 to 28 days was slightly different due to the difference of antibiotics,with the highest value being azithromycin 12 and the lowest value being cefuroxime 6.82.CONCLUSIONS In addition to the evaluation index of the utilization rate of antibiotics,the indications of antibiotics,the number of days of antibiotics treatment and the prescribed daily dose of antibiotics can also be used to evaluate the use of antibiotics in children.
antibacterial drugschildrendays of treatmentlength of therapyprescribed daily dose
NETL
NSTL
万方数据
维普
