Effect evaluation of hypoproteinemia on voriconazole trough concentration in patients based on propensity score matching
OBJECTIVE To investigate the effect of hypoproteinemia on the blood trough concentration of voriconazole in patients.METHODS A total of 322 patients with voriconazole blood concentration detected by the 900th Hospital of Joint Logis-tic Support Force from July 2017 to February 2023 were retrospectively selected.There were 175 cases in the hypoproteinemia group and 147 cases in the non-hypoproteinemia group.Propensity score matching was used to perform a 1:1 match for the hypo-proteinemia group and the non-hypoproteinemia group in order to obtain covariation-balanced samples between the groups.The effects of hypoproteinemia and non-hypoproteinemia groups on voriconazole concentration were compared.RESULTS After pro-pensity score matching,the hypoproteinemia group and the non-hypoproteinemia group both involved 69 patients,and there was no statistical difference in voriconazole trough concentration between the two groups(P＞0.05).CONCLUSION Hypoprotein-emia had no significant effect on voriconazole trough concentration in patients.
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