Research progress in the inhibition of main protease activity of SARS-CoV-2 with traditional Chinese medicine based on the strategy of ingredient-single drug-prescription
Novel coronavirus(SARS-CoV-2)has posed a serious threat to human health since its outbreak.Main protease(Mpro),as the main enzyme involved in viral gene replication and transcription,is an important target for the study of anti-novel coronavirus drugs.For corona virus disease 2019,traditional Chinese medicine(TCM)has great potential for prevention and treatment,and some TCM compound developed on the basis of classical formulas have been applied in clinical practice with good results.This paper reviewed the research progress in SARS-CoV-2 Mpro and related Chinese medicine inhibitors on the basis of three levels,namely,natural active ingredient-single drug-prescription,with a view to providing ideas for the development of potent TCM and TCM compound against SARS-CoV-2.
SARS-CoV-2main proteasenatural active ingredientsprescriptionresearch progress
NETL
NSTL
万方数据
