Effect of food on the pharmacokinetics of esomeprazole magnesium,pantoprazole sodium,and rabepra-zole sodium
OBJECTIVE This study is based on the bioequivalence test of proton pump inhibitors(PPIs),to explore the changing law of pharmacokinetic parameters under different conditions of drug administration,and to provide a basis for the ratio-nal use of drugs in the clinic.METHODS 217 healthy Chinese volunteers were given single-dose oral administration of PPIs ana-logues(esomeprazole magnesium enteric capsules 40 mg,pantoprazole sodium enteric tablets 40 mg,or rabeprazole sodium enteric tablets 10 mg)under fasting or eating conditions,and venous blood samples were collected according to the protocol requirements,and the concentrations of PPIs analogues in human plasma were determined by the UPLC-MS/MS method,respec-tively,and Phoenix WinNonlin 8.2 statistical software was used to calculate pharmacokinetic parameters.RESULTS Postpran-dial administration of esomeprazole magnesium was associated with a significant increase in Tmax and a decrease in Cmax and AUC;pantoprazole sodium was associated with an increase in Tmax and a decrease in AUC;and rabeprazole sodium was associated with an increase in Tmax,Cmax and AUC.CONCLUSION Food delays the absorption of PPIs and affects bioavailability,and is clini-cally appropriate for administration on an empty stomach.
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