A cross-sectional study of potential drug interactions with Nematavir/Ritonavir and clinical pharmacists intervening
OBJECTIVE To understand the pDDIs in clinical application of Nematavir/Ritonavir tablets(NMVr),and to investigate the value of clinical pharmacists'intervention and pharmaceutical care.METHODS Based on the NMVr pDDIs checklist in Tongji hospital,a cross-sectional study was conducted to retrospectively analyze the occurrence of pDDIs in patients who used NMVr in Tongji hospital from December 1,2022 to February 28,2023,and the clinical pharmacists intervention mea-sures and the occurrence of ADRs were summarized and analyzed.RESULTS A total of 163 patients were included and 279 cases of pDDIs occurred,involving 38 kinds of drugs and 10 classes of drugs.Cardiovascular drugs and glucocorticoid drugs were the most frequent occurrence(accounting for 40.5％and 31.9％).According to the causal criteria for adverse drug reactions,a total of 14 cases of ADRs occurred during hospitalization,involving combined drugs such as nifedipine,esazolam,dexametha-sone,etc.The clinical manifestations were mild,mainly including fatigue,dizziness,palpitation,diarrhea,headache,most ADRs got better after symptomatic treatment and had little effect on the original diseases.CONCLUSION As a new antiviral drug,NMVr has a high incidence of pDDIs in clinical practice,which should be paid close attention by clinical pharmacists and doctors.Pharmaceutical care can reduce the risk of drug interaction,provide a basis for clinicians to adjust drug therapy regimen,and avoid the occurrence of serious adverse events.
Nematavir/Ritonavirpotential drug-drug interactionsadverse drug reactioncross-sectional study
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