Study on the correlation between Let-7a-2 rs629367 or pri-miR-218 rs11134527 and toxicity induced by platinum-based chemotherapy in lung cancer patients
OBJECTIVE To investigate the correlation between Let-7a-2 rs629367 or pri-miR-218 rs11134527 and platinum-based chemotherapy toxicity in lung cancer patients,and to explore their potential as biomarkers for predicting toxicity.METHODS Totally 467 patients with lung cancer who received at least two cycles of platinum-based chemotherapy were enrolled.The rs629367 and rs11134527 were genotyped by time-of-flight mass spectrometry.The Chi-squared test was used to analyze the correlation between side effects and clinical characteristics.Unconditional logistic regression analysis was conducted to evaluate the associations.RESULTS The alleles at the rs629367 and rs11134527 loci were not significantly correlated with the total toxicity,gastrointestinal toxicity,and blood toxicity of platinum-based chemotherapy for lung cancer.Through stratified analysis,it was found that rs11134527 was significantly correlated with total toxicity in the female population(additive model:adjusted OR=0.442,95％ CI=0.214-0.914,P=0.028;dominant model:adjusted OR=0.283,95％ CI=0.109-0.732,P=0.009)and gastrointestinal toxicity(additive model:adjusted OR=0.388,95％ CI=0.182-0.826,P=0.014;explicit model:adjusted OR=0.231,95％ CI=0.089-0.598,P=0.003);rs11134527 was significantly associated with blood toxicity in non-small cell lung cancer(additive model:corrected OR=0.655,95％ CI=0.452-0.950,P=0.026;dominant model:corrected OR=0.497,95％ CI=0.300-0.826,P=0.007)and adenocarcinoma of lung(additive model:corrected OR=2.063,95％ CI=1.187-3.585,P=0.010).CONCLUSION There is no correlation between Let-7a-2 rs629367 and the toxicity of platinum-based che-motherapy in lung cancer.Pri-miR-218 rs11134527 is significantly associated with the total and gastrointestinal toxicity of plati-num chemotherapy in female lung cancer patients,as well as blood toxicity in non-small cell lung cancer,especially lung adenocar-cinoma patients.It may serve as a candidate biomarker for predicting platinum chemotherapy related adverse reactions in this population.
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