Drug utilization review of carboprost tromethamine based upon weighted TOPSIS method
OBJECTIVE To establish reasonable evaluation criteria for rational use of carboprost tromethamine(CT)and provide references for its rational application in clinical practices.METHODS Based upon the package insert for CT along with the relevant guidelines and literature,a set of criteria were formulated for evaluating its rationality through expert consultations.Using the weighted TOPSIS method of hierarchical attribute model,the usages of CT for 563 patients were evaluated at Fujian Maternity & Children's Health Hospital in 2022.RESULTS Among them,143 cases(25.40％)were judged as rational,376 cases(66.79％)basically rational and 44 cases(7.82％)irrational.Irrational use was mostly caused by inappropriate indications,contraindications,cautious uses,dosing timing and drug interactions.And there were instances of off-label use in indications,dos-ing route and timing.CONCLUSION Weighted TOPSIS method may be employed for evaluating the use of CT.And CT has been prescribed basically rationally.However,instances of irrational use require strengthened management.
weighted TOPSIS methodcarboprost tromethaminedrug use evaluation
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