季铵化两亲碳渣外用抗菌凝胶剂的药效学评价
Pharmacodynamic evaluations of quaternized amphiphilic carbonaceous particles topical antimicrobial gel
李珊珊 1王雪平 2明白露 3吴强2
作者信息
- 1. 开封大学医学部,河南开封 475003
- 2. 河南大学药学院,河南开封 475004
- 3. 开封市第五人民医院医学影像科,河南开封 475003
- 折叠
摘要
目的:对季铵化两亲碳渣外用抗菌凝胶剂(quatemized amphiphilic carbonaceous particles topical antimicrobial gel,TAG/QACPs)在抗皮肤破损领域的潜在应用进行相关药效学评价.方法:通过平板涂布法,考察TAG/QACPs对金黄色葡萄球菌、大肠杆菌、白色念珠菌的活性影响;建立小鼠伤口感染模型,考察TAG/QACPs对受损创面的影响;通过家兔皮肤刺激性试验、过敏性试验,考察TAG/QACPs的应用安全性.结果:QACPs添加量为0.3 mg·g-1时,TAG/QACPs对受试菌的杀菌率可达99.9％;能够抑制小鼠伤口感染,14d内使小鼠伤口愈合率达到98.86％;家兔完整皮肤未出现刺激反应和过敏反应.结论:TAG/QACPs是一种安全、有效、能够促进伤口愈合的新型外用抗菌制剂.
Abstract
OBJECTIVE To conduct pharmacodynamic evaluations of quaternized amphiphilic carbonaceous particles topical antimicrobial gel(TAG/QACPs)for its potential application for skin wound.METHODS The effects of TAG/QACPs on the activities of Staphylococcus aureus,Escherichia coli and Candida albicans were examined by spread plating.And the effects of TAG/QACPs on the wounds of the injured mice models were assessed.The safety of TAG/QACPs was analyzed by skin irrita-tion and skin allergy tests in rabbits.RESULTS The bactericidal rate of TAG/QACPs for the tested microorganism was 99.9％at an addition volume of 0.3 mg·g-1 QACPs.Wound healing rate of injured mice models within 14 days was 98.86％after using this agent.No irritation or allergic reaction occurred after plating this agent onto the skin of rabbits.CONCLUSION TAG/QACPs is a safe and effective antibacterial agent capable of promoting skin wound healing.
关键词
两亲碳渣/季铵化/皮肤伤口感染/凝胶剂/药效学评价Key words
amphiphilic carbonaceous particles/quaternized/skin wound infection/gel/pharmacodynamic evaluation引用本文复制引用
出版年
2024
NETL
NSTL
万方数据