Pharmacodynamic evaluations of quaternized amphiphilic carbonaceous particles topical antimicrobial gel
OBJECTIVE To conduct pharmacodynamic evaluations of quaternized amphiphilic carbonaceous particles topical antimicrobial gel(TAG/QACPs)for its potential application for skin wound.METHODS The effects of TAG/QACPs on the activities of Staphylococcus aureus,Escherichia coli and Candida albicans were examined by spread plating.And the effects of TAG/QACPs on the wounds of the injured mice models were assessed.The safety of TAG/QACPs was analyzed by skin irrita-tion and skin allergy tests in rabbits.RESULTS The bactericidal rate of TAG/QACPs for the tested microorganism was 99.9％at an addition volume of 0.3 mg·g-1 QACPs.Wound healing rate of injured mice models within 14 days was 98.86％after using this agent.No irritation or allergic reaction occurred after plating this agent onto the skin of rabbits.CONCLUSION TAG/QACPs is a safe and effective antibacterial agent capable of promoting skin wound healing.
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