Cost-effectiveness and cost-utility of Chinese and Western gargles for chronic periodontitis patients
OBJECTIVE To compare three kinds of periodontitis care schemes through cost-effectiveness and cost-utility to provide rationales for a proper treatment of periodontitis.METHODS A total of 106 patients with periodontitis were randomized into 3 groups to receive basic periodontal treatment plus compound chlorhexidine gargle(n=38),compound chlorhexidine gargle plus Sipaii gingival consolidation solution(n=35)and compound chlorhexidine gargle plus Kangfuxin gargle(n=33).Baseline pro-files,treatment expenses,effective rate and EQ-5D-3L scale score were recorded.Cost-effectiveness and cost-utility analyses were performed.Cost-effectiveness ratio(CER)was based upon total cost(C)/efficiency(E)and cost-utility.Health utility val-ues were converted by EQ-5D-3L China effect value score system.Quality-adjusted life years(QALYs)=reported survival time X health utility value.And cost-utility ratio(CUR)=total cost(C)/QALYs.RESULTS The effective rates before and after treatment were compared among three groups.After treatment,the effective rates of three groups were 78.95％,91.43％and 87.88％(H=6.753,P=0.034).There were significant differences.Cost-effectiveness ratio was 1629.98,1486.94 and 1516.52;Before treatment,utility values of three groups were 0.92,0.89 and 0.90;After rehabilitation,utility values were 0.98,0.98 and 0.97,respectively.Cost-utility ratio of three groups was 270.18,190.41 and 240.13.Treatment expense was lower than per capita GDP of Jiangsu Province for each increment of one effective rate and one QALYs.It indicated that treatment cost was completely worthwhile.The ratios of cost-effectiveness and cost-utility were similar.Both were the lowest in compound chlorhexidine plus Xipayi gingival consolidation fluid group.It indicated that compound chlorhexidine plus Xipayi gingival consoli-dation fluid group achieved the same therapeutic effect with a minimal expense.CONCLUSION For periodontitis patients receiv-ing basic periodontal basic care,a combination of compound chlorhexidine gargle and Xipayi gingival solidifying solution may sig-nificantly improve the efficiency and economy of periodontal treatment.
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