Literature analysis of oral vancomycin in the treatment of skin adverse reactions caused by Clostridium dif-ficile infection
OBJECTIVE To explore the treatment of oral vancomycin for skin adverse reaction caused by Clostridium diffi-cile infection.METHODS Domestic and foreign databases were searched from the inceptions until July 2023.The relevant litera-tures were retrieved and the related data extracted for descriptive statistical analysis.RESULTS A total of 15 patients were recruited,including 9 males and 6 females.All of them had an indication of antibiotic use and vancomycin was prescribed for C.difficile infection.In terms of age,there were 2 children and 8 patients were 65 years and above.Five cases developed kidney injury.Oral dose of vancomycin was ≥500 mg·d-1(n=11).Skin adverse reactions included red man syndrome,maculopapular rash and linear IgA bullous dermatosis.Blood concentration of vancomycin was(0.1-28.7)mg·mL-1(n=5).In terms of adverse reaction management,drug was discontinued(n=14)and antihistamines offered(n=12).For 4 cases on anti-C.diffcile regimen,fedamycin(n=1)and metronidazole(n=3)were prescribed.All of them had varying degrees of improvements and 2 cases died from underlying diseases.CONCLUSION During the treatment of C.diffcile infection,oral vancomycin may be absorbed throughout body and leads to rash.Greater attention should be paid to high-risk groups.
NETL
NSTL
万方数据
