Curative efficacy of dexzopiclone plus oryzanol tablet on anxiety insomnia and its influences on related neurotransmitters in perimenopausal women
OBJECTIVE To explore the curative efficacy of dexzopiclone assisted oryzanol tablets on anxiety insomnia and its influences on neurotransmitters in perimenopausal women.METHODS Between January 2020 and January 2023,202 peri-menopausal women hospitalized at Hengshui People's Hospital were recruited.They were assigned into two groups of control(dexzopiclone tablets)and observation(dexzopiclone tablets plus oryzanol tablets).Before and after treatment,sleep quality and anxiety status of subjects were evaluated by Pittsburgh sleep quality index(PSQI)and Hamilton anxiety scale(HAMA).The serum levels of 5-hydroxytryptamine(5-HT),y-aminobutyric acid(GABA),noadrenaline(NE),dopamine(DA),brain-derived neurotrophic factor(BDNF),neurotrophic factor 3(NT-3),nerve growth factor(NGF),follicle-stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E2)were detected.Adverse reactions were statistically compared.RESULTS After treatment,points of PSQI/HAMA were significantly lower in observation group than those in control group(P＜0.05).As compared with control group,sleep quality was significantly better and anxiety degree significantly milder in observation group(P＜0.05).The levels of 5-HT,GABA,BDNF,NT-3,NGF and E2 were significantly higher in observa-tion group than those in control group while the levels of NE,DA,FSH and LH significantly lower than those in control group(P＜0.05).No significant inter-group difference existed in the incidence of adverse reactions(P＞0.05).CONCLUSION Dexzopiclone plus oryzanol tablets may improve anxiety insomnia in perimenopausal women.
NETL
NSTL
万方数据
