Evaluations of etiological characteristics and anti-infection regimens of diabetic foot infection at a tertiary hospital
OBJECTIVE To evaluate the etiological characteristics and rationality of anti-infection regimens for diabetic foot infection at a tertiary hospital.METHODS From January 2017 to March 2023,the relevant clinical data were retrospectively reviewed for 98 patients hospitalized for diabetic foot infection with a positive culture and a drug sensitivity result.Patient status,laboratory parameters and pathogenetic characteristics were recorded.The rationality of empirical and targeted anti-infection regi-mens was evaluated by setting evaluation criteria along with patient status and etiologic outcomes.RESULTS Infection was mild(n=30),moderate(n=50)and severe(n=18).And leucocyte count,neutrophil percentage,C-reactive protein and procalcitonin differed greatly among patients with varying severity of infection(P＜0.05).Among 104 pathogenic strains,there were aerobic gram-positive cocci(n=85),aerobic Gram-negative enterobacter(n=13)and aerobic non-fermented Gram-negative bacilli(n=6).The rates of irrational anti-infection regimens of empirical and targeted treatment were 64.6％and 63.6％.Nitroimidazoles in combination with other drugs with anti-anaerobic activity was a major reason for irrational use of both empirical and target treat-ments,accounting for 49 cases(92.5％)and 38 cases(77.6％)respectively.CONCLUSION Selecting antibiotics for diabetic foot infection patients is inappropriate at this hospital.Unnecessary combination of drugs should be minimized.
diabetic foot infectionetiologyantibioticsrational drug use
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