奥沙利铂致急性胰腺炎1例
Acute pancreatitis induced by oxaliplatin:one case report
赵晨 1周海辉 2王晶1
作者信息
- 1. 南京中医药大学附属南京中医院药学部,江苏南京 210001
- 2. 南京大学医学院附属鼓楼医院药学部,江苏南京 210008
- 折叠
摘要
药源性胰腺炎是由药物或代谢产物与机体之间异常相互作用引起的机体特异质反应或超敏反应而造成的胰腺损伤,发生率较低.奥沙利铂是第3代铂类抗肿瘤药物,常与5-FU和亚叶酸钙联合用于结直肠癌的治疗.奥沙利铂的主要不良反应为剂量限制性外周神经毒性、胃肠道反应和骨髓抑制等,关于其诱发急性胰腺炎的报道和讨论较少.本文就1例奥沙利铂致急性胰腺炎进行分析,旨在为防治该不良反应提供参考.
Abstract
Drug-induced pancreatitis is a rare disease char-acterized by specific reactions or hypersensitivity responses leading to pancreatic injuries.It results from abnormal interac-tions between drugs or their metabolites and human body.Oxaliplatin,a third-generation platinum-based anti-neoplasm agent,is commonly applied in combination with 5-fluorouracil and calcium folinate for colorectal cancer.The primary adverse reactions associated with oxaliplatin include dose-limiting peripheral neurotoxicity,gastrointestinal reactions and myelosuppression.There are few reports and discussions of its potential of inducing acute pancreatitis.This review focused upon one case of oxaliplatin-induced acute pancreati-tis.It was intended to provide references for managing adverse reactions.
关键词
奥沙利铂/急性胰腺炎/不良事件Key words
oxaliplatin/acute pancreatitis/adverse events引用本文复制引用
出版年
2024
NETL
NSTL
万方数据