Evaluating antimicrobial activities against common pathogenic bacteria of extracts from different parts of Potentilla discolor Bunge
OBJECTIVE To screen the active antibacterial parts of Potentilla discolor Bunge(PDB)and reveal its active antibacterial components of extracts from different parts of PDB against common pathogenic bacteria.METHODS The solvent extractions were utilized for harvesting the extracts of PDB different parts.Microdilution method was employed for detecting the antibacterial activity.Spearman's analysis was utilized for examining the correlation between chemical components and antibacte-rial activity.RESULTS The contents of total flavonoids and total phenols differed greatly in extracts of PDB different parts.Ethyl acetate fraction was the greatest,followed by n-butanol fraction.Antibacterial activity results indicated that all extracts from PDB different parts exhibited antibacterial potency against tested strains and antibacterial effect on Gram-positive bacteria was bet-ter than Gram-negative bacteria.The antibacterial effects of extract from different parts were the strongest in ethyl acetate frac-tion,followed by n-butanol fraction and the weakest in water fraction.Correlation analysis revealed a significant correlation between the content of total flavonoids and the antibacterial effect of all tested strains.As for correlation between total phenols and antibacterial effect of tested strains,only part of them reached significant levels.CONCLUSION The extracts of PDB different parts possess antibacterial activities.And ethyl acetate fraction has the strongest antibacterial potency.Two active antibacterial components are flavonoids and phenols.This study provides theoretical rationales for the development and utilization of PDB for its clinical antibacterial potency and medicinal value.
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