Optimization of particle forming process of traditional Chinese medicine formulation based upon Plackett-Burman and G1-entropy weight design plus Box-Behnken response surface method:Xiao'er Resuqing Granules as an example
OBJECTIVE As an important step in the production of Chinese medicine formula particles,molding process is correlated closely with the quality and efficacy of particles.In actual production researches,molding process is examined by single factor test or single factor plus orthogonal experiment.Here the authors attempted to establish an optimal molding process of Xiao'er Resuqing Granules based upon Plackett-Burman and G1-entropy weight design plus Box-Behnken response surface method.METHODS With secondary forming rate,moisture absorption rate,angle of rest and melting rate as indices,Plackett-Burman design was adopted for selecting suitable factors and levels through single factor experiment and then key process parameters were determined.The forming process of Xiao'er Resuqing Granules was optimized based upon G1-entropy weight method and response surface design.RESULTS After optimization,the mass ratio of drug-to-drug was 7∶3,mass ratio of dextrin-to-mannitol 1∶1,mass fraction of aspartan 0.3％and mass fraction of peach essence 0.2％.Process:80％ethanol(2％PVP-K30)was granulated with a wetting agent and dried for 1 h at 60 ℃.The average comprehensive score was 94.46.CONCLUSION The above preparation process is reliable,stable and repeatable.It may be applied for optimizing the molding process of Xiao'er Resuqing Granules.
Xiao'er Resuqing Granulesdesign of Plackett-BurmanG1-entropy weight methodBox-Behnken response sur face method
NETL
NSTL
万方数据
