摘要
目的:评价益生菌的应用在青少年肥胖患者中的临床疗效及对患者肠道微生物群组的影响,为治疗青少年肥胖症提供新的方法.方法:选取2022年1月至2023年1月就诊于石家庄市人民医院内分泌科的青少年肥胖患者60例,性别不限,用随机数字表法分为观察组(30例)和对照组(30例).2组均给予饮食、运动指导,观察组在此基础上口服益生菌(双歧杆菌四联活菌片,规格:每片0.5g).2组均进行为期12周的益生菌干预,观察研究组及对照组干预前后体质量指数(BMI)、BMI百分位、腰臀比、体脂率、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、肠道球菌与杆菌比例的变化.结果:干预12周后,观察组的BMI、TC、TG、LDL-C及肠道球菌数量较对照组下降,差异具有统计学意义,P＜0.05.结论:应用益生菌可调节青少年肥胖患者的肠道菌群结构,改善BMI、腰臀比、体脂率及脂代谢相关指标,为防治青少年肥胖提供一种新型、可靠的治疗方法.
Abstract
OBJECTIVE To evaluate the clinical efficacy of probiotics and examine their effects upon intestinal microbiota in adolescent obese patients so as to provide a new treatment of adolescent obesity.METHODS From January 2022 to January 2023,60 adolescent obese patients were recruited from Department of Endocrinology of Shijiazhuang People's Hospital.They were randomized into two groups of observation(n=30)and control(n=30).Both groups received dietary and exercise guidance while observation group had additional oral probiotics(Bifidobacterium quadruple viable tablets,specification:0.5 g/tablet).After a 12-week probiotic intervention,the changes in body mass index(BMI),BMI percentile,waist-to-hip ratio,body fat per-centage,total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cho-lesterol(HDL-C)and ratio of enterococci to bacilli were observed before and after intervention in both groups.RESULTS After 12 weeks of intervention,the levels of BMI,TC,TG,LDL-C and enterococci declined in observation group as compared with control group and the differences were statistically significant(P＜0.05).CONCLUSION The application of probiotics may regulate intestinal microbiota structure,improve BMI,waist-to-hip ratio,body fat percentage and lipid metabolism related indica-tors in adolescent obese patients.Thus it provides a new and reliable management of adolescent obesity.
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