Effects of α-lipoic acid on serum uric acid and renal function in patients of type 2 diabetes mellitus
OBJECTIVE To explore the impact of α-lipoic acid(ALA)on the level of serum uric acid(SUA)and renal function in patients of type 2 diabetes mellitus(T2DM).METHODS A retrospective single-arm before-after controlled study was performed for 163 patients on a therapy of ALA between January 2017 and December 2022.Gender,age,diabetic duration,SUA,estimated glomerular filtration rate(eGFR)and complications were employed as indicators for assessing the changes in SUA,SUA/creatinine ratio and eGFR before and after treatment.Correlation and multiple linear regression analyses were per-formed with baseline SUA as a dependent variable.RESULTS Overall analysis revealed a significant reduction in SUA level after ALA dosing(P＜0.01).Stratified analysis demonstrated a significant reduction in SUA level exclusively in patients aged ≥50 years or with a baseline level of SUA＜480 μmol·L-1(P＜0.01).Notably,ALA dosing significantly improved eGFR in patients of moderate-to-severe renal function impairment prior to treatment.Multiple linear regression analysis identified baseline level of SUA(P＜0.01)as a primary influencing factor for changes in SUA before and after treatment.CONCLUSION ALA is effective in lowering the level of SUA in T2DM patients aged ≥50 years and those with pre-treatment SUA＜480 μmol·L-1.Furthermore,it has also demonstrated some promise in enhancing renal function in T2DM patients with moderate-to-severe eGFR reduction.It offers potential therapeutic options for managing hyperuricemia in T2DM and provides valuable insights into a novel application of ALA.
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