Rhabdomyolysis induced by polymyxin B:one case report
An 85-year-old male of ascending colonic can-cer developed pulmonary infection caused by Pan drug resis-tant Acinetobacter baumannii on the 20th day after laparo-scopic assisted radical resection of right colon under general anesthesia.Polymyxin B 500 000 U qid was prescribed along with tigecycline 50 mg q12h for anti-infection.After dosing of polymyxin B,serum level of creatine kinase(CK)spiked pro-gressively and peaked at 5 804 U·L-1.It was probably rhab-domyolysis(RM)caused by polymyxin B.After 7-day treat-ment,a steady-state plasma concentration of polymyxin B was attained at 2.1 mg·L-1.After a discontinuation of poly-myxin B,serum creatine phosphokinase showed a downward trend and normalized.This dose-independent adverse reac-tion was a new rare class B adverse reaction.A better under-standing of rare adverse reactions helps to ensure the clinical safety of polymyxin B dosing.
NETL
NSTL
万方数据
