Effect of intraoperative intravenous magnesium sulfate infusion on quality and hemodynamics during gen-eral anesthesia awakening in elderly hypertensive patients
OBJECTIVE To explore the effect of intraoperative intravenous magnesium sulfate infusion on quality and hemo-dynamics during general anesthesia awakening in elderly hypertensive patients.METHODS A total of 60 elderly hypertensive ASA Ⅱ/Ⅲ patients aged 60 to 85 years undergoing elective knee arthroplasty were selected.They were randomized into two groups of magnesium sulfate(M)and control(C)(n=30 each).During awakening period,Richmond Agitation-Sedation Score(RASS)and Ramsay Sedation Scale were evaluated.And the occurrences of choking and agitation were recorded.MAP and HR were measured at different timepoints of admission(T0),pre-induction(T1),post-induction(T2),immediate post-intubation(T3),skin incision(T4)and intra-operation at 15 min(T5),30 min(T6),45 min(T7)and extubation(T8)in both groups.Doses of general anesthesia and vasoactive drugs during operation,as well as time of recovery of spontaneous respiration,eye-opening and extubation,were also recorded.RESULTS As compared with group C,group M had a notably lower RASS score and lower incidences of agitation and choking(P＜0.05);At T3/T8,Group M had significantly lower levels of mean arterial pressure(MAP)and heart rate(HR).Additionally,group M had significantly lower MAP at T4(P＜0.05).Although intraoperative dose of propofol did not differ significantly between groups,dose of remifentanil was considerably lower in group M(P＜0.05).Group M had longer recovery for spontaneous respiration,eye-opening and extubation.However,interval between recovery of spontaneous respiration and extubation was notably shorter in group M(P＜0.05).CONCLUSION An intraoperative intrave-nous infusion of magnesium sulfate may provide stable hemodynamics and improve the quality of awakening for elderly hyperten-sive patients undergoing knee arthroplasty.
magnesium sulfateelderlyhypertensionquality of awakeningagitation
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