首页|卡瑞利珠单抗致声音嘶哑1例

卡瑞利珠单抗致声音嘶哑1例

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67岁男性肝恶性肿瘤患者,在卡瑞利珠单抗联合化疗治疗3个周期后出现声音嘶哑.排外肿瘤脑转移,声带损伤等原因后考虑为药物引起的声音嘶哑.予以停用卡瑞利珠单抗后患者声音嘶哑改善.目前已有1例卡瑞利珠单抗相关声音嘶哑的报道,其他免疫检查点抑制剂(immune check-point inhibitors,ICIs)相关6例,但这些病例声音嘶哑都继发于肌病、神经病变或感染等不良反应.该文报道的患者声音嘶哑为唯一不良反应症状,并不继发于其他不良反应.
Dysphonia induced by camrelizumab:one case report
A 67-year-old male was diagnosed with a hepa-toma.After three sessions of camrelizumab plus chemo-therapy,there was an onset of dysphonia.As brain metastases and vocal cords disease were excluded,drug-related disorder was suspected and camrelizumab dosing discontinued.At Day 60,the symptom of hoarseness disappeared.Only 1 case of camrelizumab and 6 cases of other ICIs-related dysphonia have been described so far.Our case stood out for isolated dysphonia without any other adverse reactions of myopathy and infection.

camrelizumabdysphonialiver cancer

王永宽、黄妮娅、李寅珊、马玲

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云南省第一人民医院,昆明理工大学附属医院临床药学,云南昆明 650032

曲靖市会泽县人民医院药剂科,云南曲靖 654200

卡瑞利珠单抗 声音嘶哑 肝恶性肿瘤

2024

中国医院药学杂志
中国药学会

中国医院药学杂志

CSTPCD北大核心
影响因子:1.198
ISSN:1001-5213
年,卷(期):2024.44(13)
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