达比加群酯致抗凝剂相关肾病1例
Anticoagulant related nephropathy induced by dabigatranet exilate:one case report
谌甜甜 1邹娟 2魏安华3
作者信息
- 1. 华中科技大学同济医学院附属同济医院药学部,湖北武汉 430033;湖南旺旺医院药学部,湖南长沙 410016
- 2. 华中科技大学同济医学院附属同济医院药学部,湖北武汉 430033;武汉科技大学附属天佑医院药学部,湖北武汉 430064
- 3. 华中科技大学同济医学院附属同济医院药学部,湖北武汉 430033
- 折叠
摘要
抗凝剂相关肾病(anticoagulant-related nephropa-thy,ARN)是一种由抗凝剂过度抗凝引起的药品不良反应,显著增加患者死亡风险.新型口服抗凝剂此类报道少见,易被临床误诊或忽视.本文报道1例阵发性心房颤动患者接受达比加群酯等药物治疗后出现急性肾损伤,伴有血尿、蛋白尿及凝血功能异常的罕见病例,分析其诱发ARN的高危因素,通过停药、护肾、促排等治疗后成功好转,同时对国内外报道文献进行梳理,以期为ARN的诊断与处置提供借鉴.
Abstract
Anticoagulant-related nephropathy(ARN)is an adverse drug reaction of excessive anticoagulation.With a high mortality rate,it may be easily misdiagnosed or ignored in clinical practices.Novel oral anticoagulants have been rarely mentioned.Here the authors reported one case of par-oxysmal atrial fibrillation.After the patient taking dabigatran etexilate and other drugs,acute kidney injury was associated with hematuria,proteinuria and abnormal coagulation.The high-risk factors were discussed for ARN induced by dabiga-tran etexilate.After dabigatran etexilate withdrawal,kidney supportive care and excretion enhancement,he recovered eventually.Both domestic and foreign literatures were reviewed for providing references for proper managements of ARN.
关键词
达比加群酯/抗凝剂相关肾病/急性肾损伤/药品不良反应Key words
dabigatran etexilate/anticoagulant related nephropathy/acute kidney injury/adverse drug reaction引用本文复制引用
出版年
2024
NETL
NSTL
万方数据