Research advances on pharmacological mechanism of active components of Angelica sinensis in the treat-ment of osteoarthritis
Osteoarthritis(OA)is a common chronic age-related orthopedic disease.And inflammation and cartilage degenera-tion play a key role in its pathogenesis.In recent years,with the deepening of researches on Chinese medicine,Chinese medicine has been widely applied for managing OA.Blood-activating and blood-stasis-removing herbal medications may effectively arrest nflammation and delay cartilage degeneration.It offers potential drug resources for preventing and treating OA.Angelica sinensis is a common blood-activating and stasis-eliminating herb.Pharmacological studies have demonstrated that the active ingredients of ferulic acid(FA),Angelica sinensis polysaccharide(ASP)and ligustilide(LIG)could effectively treat OA through suppressing inflammatory responses,arresting extracellular matrix degradation,regulating chondrocyte metabolism and impeding cartilage apoptosis of chondrocytes.This review summarized the latest advances and breakthroughs for ASP in the prevention and treat-ment of OA.It was intended to provide scientific rationales for further basic researches and drug developments.
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