蛋白琥珀酸铁加重婴儿肝损伤1例
Infantile liver injury aggravated by iron protein-succinylate:one case report
李紫薇 1黄怡蝶 1沈茜 2徐虹 2李智平1
作者信息
- 1. 国家儿童医学中心/复旦大学附属儿科医院临床药学部,上海 201102
- 2. 国家儿童医学中心/复旦大学附属儿科医院肾脏内科,上海 201102
- 折叠
摘要
贫血是慢性肾脏疾病患者的常见并发症之一,铁剂常用于治疗肾性贫血.肝脏是铁储存的主要场所.已有证据表明长期铁治疗会导致肝脏铁超载的风险.该文报道了1例婴儿应用蛋白琥珀酸铁后肝损伤加重,并阐明了铁可以通过诱导铁死亡导致肝损伤和肝纤维化的机制,对于今后临床上长期应用铁剂治疗贫血起到了一定的警示作用.
Abstract
ABSTRACT:Anemia is one of common complication in patients with chronic kidney disease.Iron supplement is a standard treatment for renal anemia.Liver is a major site of iron storage.Growing evidence suggests that long-term iron therapy is associated with a risk of hepatic iron overload.This report described one infant with aggravated liver injury after dosing of iron protein succinylate.It elucidated the mecha-nism by which iron overload causes liver damage and liver fibrosis through inducing ferroptosis.It provides a warning for long-term application of iron in the treatment of anemia in the future.
关键词
贫血/铁过载/肝损伤Key words
anemia/iron overload/liver injury引用本文复制引用
出版年
2024
NETL
NSTL
万方数据