贝伐珠单抗、呋喹替尼致高血压、肾病综合征1例
Hypertension and nephrotic syndrome induced by bevacizumab and fuquitinib:one case report
梁紫微 1吴娜 2孟凡堰1
作者信息
- 1. 安顺市人民医院药剂科,贵州安顺 561000
- 2. 安顺市人民医院肿瘤科,贵州安顺 561000
- 折叠
摘要
通过1份老年男性患者使用贝伐珠单抗、呋喹替尼引起高血压、肾病综合征的病例资料与相关文献进行回顾分析.患者使用贝伐珠单抗、呋喹替尼后出现血压升高达190/110 mmHg、大量蛋白尿(17.36 g·d-1),血清白蛋白降至24.4g·L-1,双下肢水肿,考虑为贝伐珠单抗、呋喹替尼所致高血压、继发性肾病综合征可能性大,经停用呋喹替尼、血液净化治疗与对症支持处理后有所好转.提示贝伐珠单抗、呋喹替尼可能会导致高血压、肾病综合征,临床使用该类药物时需警惕类似药物不良反应的发生.
Abstract
Hypertension and nephrotic syndrome induced by bevacizumab and fuquitinib in an elderly male was analyzed with a review of the relevant literature.After dosing of bevaci-zumab and fuquitinib,there was an onset of elevated blood pressure(190/110 mmHg),massive proteinuria(17.36 g·d-1),lower level of serum albumin(24.4g·L-1)and edema of both lower extremities.There was a high possibility of hyper-tension and secondary nephrotic syndrome due to bevacizumab and fuquitinib.The symptoms improved after a withdrawal of fuquinitinib,blood purification and symptomatic supports.
关键词
贝伐珠单抗/呋喹替尼/高血压/肾病综合征/抗VEGF抑制剂Key words
bevacizumab/fuquitinib/hypertension/nephrotic syndrome/anti-VEGF inhibitor引用本文复制引用
出版年
2024
NETL
NSTL
万方数据