摘要
肾移植患者长期使用免疫抑制剂,其感染COVID-19的风险增加.该例报告中,肾移植患者长期使用他克莫司(tacrolimus,TAC)预防排斥反应,感染COVID-19引起TAC血药浓度异常升高.通过文献复习,对造成TAC血药浓度升高的病理因素以及因TAC血药浓度升高导致的肝损伤、肾损伤等不良反应进行分析,为今后感染COVID-19的肾移植患者病理因素分析,以及TAC血药浓度异常引起的不良反应防治提供参考.
Abstract
An elevated risk of COVID-19 is due to long-term use of immunosuppressants in kidney transplant(KT)recipients.In this report,one patient received tacrolimus(TAC)for a long time to prevent rejection.And COVID-19 caused an abnormal blood drug concentration of TAC.Patho-logical factors and adverse heptorenal reactions leading to an elevated level of TAC were examined through a literature review.It provided references for analyzing pathological fac-tors in COVID-19 KT recipients and preventing adverse reac-tions of an abnormal blood concentration of TAC.
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