Clinical efficacy and safety of Zhishangfeng Granules for upper respiratory tract infection in elders
OBJECTIVE To explore the efficacy and safety of Zhishangfeng Granules for elderly upper respiratory tract infec-tions.METHODS From January 2022 to January 2023,108 outpatients/inpatients were randomized into two groups of experi-ment(Zhishangfeng Granules,n=53)and control(Fenma Meimin Tablets,n=55).The changes of vital signs,laboratory safety parameters,body temperature,traditional Chinese medicine(TCM)syndromes,efficacy and adverse reactions were compared between two groups.RESULTS Baseline profiles of two groups were comparable without statistical difference(P＞0.05).As compared with control group,experiment group had a shorter onset time for fever relief(2 h vs.6 h).Statistical difference existed between two groups(P＜0.05).Experiment was significantly better than control group in improving nasal congestion(-2;0),alleviating runny nose symptoms(-2;0)and boosting the overall score of TCM symptoms(80.4％vs.57.4％)(P＜0.05).Furthermore,no inter-group statistical differences existed in the changes of blood/urine routine or renal function after dosing.The median change value of glutamic oxaloacetic transaminase was 0.41 U·L-1 in experiment group and 2.15 U·L-1 in control group.It indicated that dosing of Zhishangfeng Granules had less impact on the change of glutamic oxaloacetic transaminase than that of Fenmameimin Tablets(P＜0.05).CONCLUSION With a faster onset time for antipyretic effects,Zhishangfeng Granules is less prone to recurrence.In terms of syndrome improvement,Zhishangfeng Granules not only significantly improves such catarrhal symptoms as nasal congestion and runny nose,but also enhances the overall score of syndromes better than Fenmameimin Tab-lets.Also Zhishangfeng Granules has demonstrated equal safety in terms of renal function,blood routine and urine routine.At the same time,it can also alleviate the injury of liver function to a certain extent.
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